Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy
نویسندگان
چکیده
منابع مشابه
QSAR Studies on Bacterial Efflux Pump Inhibitors
Antimicrobial drug resistance occurs when bacteria undergo certain modifications to eliminate the effectiveness of drugs, chemicals, or other agents designed to cure infections. To date, the burden of resistance has remained one of the major clinical concerns as it renders prolonged and complicated treatments, thereby increasing the medical costs with lengthier hospital stays. Of complex causes...
متن کاملBacterial efflux pump inhibitors from natural sources.
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia c...
متن کاملGlycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall.
Tuberculosis (TB) is the cause of more than a million deaths a year and is believed to infect a third of the world’s population. Emergent multidrug-resistant strains of Mycobacterium tuberculosis, the organism that causes the disease, and difficulties in treating immunocompromised individuals have further increased the urgency of the threat. The cell wall of mycobacteria is formed by polysaccha...
متن کاملInhibition of quorum sensing and efflux pump system by trifluoromethyl ketone proton pump inhibitors.
BACKGROUND One major microbiological problem is the widespread antibiotic resistance. There is an urgent need for new antibiotics and ways to treat multi-drug-resistant infections. Inhibition of bacterial quorum sensing (QS) systems could be an effective alternative in a smuch as they regulate a broad spectrum of cell functions, including, virulence factor production, biofilm organisation and m...
متن کاملadeabc efflux pump genes in multidrug resistant acinetobacter baumannii isolates
conclusions adeabc efflux system plays a vital role in multidrug resistance in clinical a. baumannii isolates. it was noted that the most important gene responsible for multidrug resistance within this system was the adeb gene especially in carbapenems resistance. methods this study was conducted on 84 multidrug resistant and 13 carbapenem-susceptible a. baumannii isolates obtained from burn an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2015
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkv316